Lockdown diaries - COVID-19 matters!

What are you going to be doing during the lockdown?

  • At home. I’m non essential

    Votes: 70 41.2%
  • Working. The virus doesn’t scare me

    Votes: 41 24.1%
  • On standby

    Votes: 10 5.9%
  • Working from home. Too essential to take any risk!

    Votes: 66 38.8%

  • Total voters
    170
  • Poll closed .
My mrs tested positive yesterday, a colleague at her office was sick. She’s ok so far with just a few symptoms and I have a few as well so I’m pretty sure I’ve got it as well now.
I tested negative yesterday, chuffed about that.

Mrs is doing ok, we figure she's on day 7 and symptons have eased up a bit so thats very good news.
 
Immunocompromised people need an additional dose: ACIP cliff notes


https://yourlocalepidemiologist.substack.com/p/immunocompromised-people-need-an

Loads of info in the article. But just a few points.

Yesterday, the FDA authorized immunocompromised an additional dose of the mRNA COVID19 vaccine.


Who needs to the additional dose?

Unfortunately, there is just not enough evidence for J&J recipients. So people with a J&J vaccine are not authorized for an additional dose.

Among those that got a mRNA vaccine before, these groups need an additional dose:

  • Active treatment for solid tumor and hematologic malignancies

  • Receipt of solid-organ transplant and taking immunosuppressive therapy

  • Receipt of CAR-T-cell or hematopoietic stem cell transplant (within 2 years of transplantation or taking immunosuppression therapy)

  • Moderate or severe primary immunodeficiency (e.g., DiGeorge, Wiskott-Aldrich syndromes)

  • Advanced or untreated HIV infection

  • Active treatment with high-dose corticosteroids (i.e., ≥20mg prednisone or equivalent per day), alkylating agents, antimetabolites, transplant-related immunosuppressive drugs, cancer chemotherapeutic agents classified as severely immunosuppressive, TNF blockers, and other biologic agents that are immunosuppressive or immunomodulatory
My notes: I think we are still very far off to approve any third shot. But some good news nevertheless.
 
Did anyone else receive this message on their phone?

Obviously women don't need to be vaccinated!!

Calling all men.png
 
People with Past COVID-19 Benefit from Immunization


https://www.jwatch.org/na53802/2021/07/08/people-with-past-covid-19-benefit-immunization

Neutralizing antibody concentrations rose by about 100-fold after vaccination.

Some patients with past SARS-CoV-2 infections think they have been “naturally immunized” and won't benefit from COVID-19 vaccination. Two new studies add to the evidence showing that vaccination generates a more vigorous B and T cell response than does natural infection and that vaccination is particularly potent in people with previous SARS-CoV-2 infections.

Researchers evaluated people who were vaccinated (with an mRNA vaccine) after natural infection and people who were vaccinated but had no prior natural infection. In people who were vaccinated after natural infections, neutralizing antibodies against the beta variant were 25 times higher than after vaccination alone and 100 times higher than after natural infection alone. This result was remarkable, given that natural infections were almost never with the beta variant and that vaccines did not target the beta-variant spike protein. Memory B cells against SARS-CoV-2 were 5- to 10-fold higher when vaccination followed natural infection than after natural infection or vaccination alone.
 
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