A coiled coil is a structural motif in proteins in which 2-7 alpha-helices are coiled together like the strands of a rope (dimers and trimers are the most common types). Many coiled coil-type proteins are involved in important biological functions such as the regulation of gene expression, e.g. transcription factors. Notable examples are the oncoproteins c-Fos and c-jun, as well as the muscle protein tropomyosin.

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